Original Article
Relationship between ALDH2 rs671 gene polymorphism and body fat content in Han population
Li Rong, Li Min, Ma Cong
Published 2023-06-20
Cite as Chin J Health Manage, 2023, 17(6): 444-448. DOI: 10.3760/cma.j.cn115624-20221206-00880
Abstract
ObjectiveTo investigate the relationship between ALDH2 rs671 gene polymorphism and body fat content in Chinese Han population.
MethodsIt was a cross-sectional study. A total of 3 943 Chinese Han people were selected for physical examination in the Department of Health Medicine in the Second Medical Center of Chinese PLA General Hospital from January 2017 to January 2020, including 2 749 males and 1 194 females; the average age was (48.12±7.98) years. The research subjects were divided into obesity group and non-obesity group according to their body fat rate. The basic information including age, gender, disease history, height, weight, body fat content and blood samples were collected; the ALDH2 rs671 gene polymorphism was detected. Genotype and allele frequencies were compared between groups by using χ² test. The comparison of clinical data between different genotypes was conducted by using one-way analysis of variance. The correlation between various indicators, lifestyle and genotype was analyzed by using a logistic regression model.
ResultsThe distribution of ALDH2 rs671 genotype was wild genotype GG (68.6%), heterozygous mutant genotype GL (28.7%) and homozygous mutant genotype LL (2.7%). In terms of baseline characteristics, there were significant differences in male (67.5% vs 71.3%), body mass index (BMI, (23.12±2.64) kg/m2 vs (27.10±2.75) kg/m2), genotype distribution (GG 65.6% vs 70.6%), drinking history (64.4% vs 68.8%), history of hypertension (18.7% vs 36.9%), coronary heart disease (3.7% vs 5.6%) and diabetes (9.7% vs 15.0%) between the obesity and non-obesity group (all P<0.05). Multifactor logistic regression showed that ALDH2-GG genotype (OR=1.386, 95%CI: 1.078-1.782), age (OR=1.051, 95%CI: 1.035-1.068), and BMI (OR=2.182, 95%CI: 2.043-2.331) were risk factors for obesity differentiated by body fat percentage, and male (OR=0.175, 95%CI: 0.123-0.250) was protective factor (all, P<0.05).
ConclusionALDH2 rs671 polymorphism is related to body fat content. The risk of excessive body fat content in individuals with GG genotype is significantly increased.
Key words:
Body composition; Obesity; Gene polymorphism; Body fat content
Contributor Information
Li Rong
Department of Health Medicine, the Second Medical Center &
National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China
Li Min
Department of Health Management, General Hospital of Xinjiang Military Region of the Chinese People′s Liberation Army, Urumqi 830000, China
Ma Cong
Department of Health Medicine, the Second Medical Center &
National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China
