Original Article
Detection and analysis of blood immune parameters in patients with chronic pancreatitis
Zhaohong Zheng, Jiulong Zhao, Tingting Du, Lianghao Hu, Zhuang Liao, Bo Ye, Bairong Li, Juntao Ji, Dan Wang, Jinhuan Lin, Zhaoshen Li
Published 2015-04-20
Cite as Chin J Pancreatol, 2015, 15(2): 93-96. DOI: 10.3760/cma.j.issn.1674-1935.2015.02.006
Abstract
ObjectiveTo explore the positive rate of each autoimmunity parameters in patients with chronic pancreatitis.
MethodsFour hundred and nine chronic pancreatitis patients treated in Department of Gastroenterology of Changhai Hospital were selected and the 25 autoimmunity parameters included anti-ENA antibody, anti-neutrophil cytoplasmic antibody, anti-β2-GPI, anticardiolipin antibody (ACA), anti dsDNA antibody were determined, then a literature search was performed to compare the autoimmune positive rate of healthy people in Pubmed database with chronic pancreatitis patients.
ResultsAmong 409 patients, the positive rates of anti β2-GPI, ACA, and anti dsDNA antibody were 11.7%, 1.4%, and 1.9%, respectively, whereas other indicators were negatively expressed. The positive rate of anti β2-GPI in CP patients was significantly higher than that of healthy group (11.7% vs 3.4%), and the positive rate of ACA was lower than that of healthy group (1.4% vs 4.1%), and the difference between the two groups was statistically significant (P<0.05).
ConclusionsAnti β2-GPI shows some potential value in the diagnosis and treatment of chronic pancreatitis, but the clinical significance of ACA is uncertain.
Key words:
Pancreatits, chronic; Autoimmune diseases; Biological markers; anti-β2 glycoprotein 1
Contributor Information
Zhaohong Zheng
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Jiulong Zhao
Tingting Du
Lianghao Hu
Zhuang Liao
Bo Ye
Bairong Li
Juntao Ji
Dan Wang
Jinhuan Lin
Zhaoshen Li