Original Article
Meta-analysis of risk factors for acute pancreatitis in pregnancy in China in recent ten years
Xiong Yuling, Tian Yue, Li Shan, Yang Jing, Gao Qing
Published 2022-12-20
Cite as Chin J Pancreatol, 2022, 22(6): 453-460. DOI: 10.3760/cma.j.cn115667-20220324-00040-1
Abstract
ObjectiveTo systematically assess the risk factors for acute pancreatitis in pregnancy (APIP) in China in recent 10 years.
MethodsAcute pancreatitis, pregnancy, risk factors and clinical features were used as search terms. Case-control studies on APIP in China were retrieved by computer from PubMed, Cochrane Library, Embase, CNKI, Wanfang, VIP and Chinese Biomedical Literature Database from December 2011 to December 2021. RevMan 5.4 software was utilized for Meta analysis.
ResultsA total of 1525 APIP patients (645 severe cases and 880 mild cases) were included in 26 literatures. Meta analysis showed that early pregnancy, late pregnancy, hyperlipidemia and biliary etiology were the risk factors for APIP. In the early pregnancy, 4.22% of patients were in the severe group and 10.43% were in the mild group; In the late pregnancy, 81.95% of the patients were in the severe group and 69.72% were in the mild group. The causes of hyperlipidemia accounted for 52.16% in the severe group and 22.69% in the mild group. The causes of biliary disease accounted for 27.96% in the severe group and 41.71% in the mild group. All the differences of the above indicators between groups were statistically significant (all P value <0.05). The age at onset, body mass index, serum C-reactive protein and triacylglycerol levels of severe patients were higher than those of mild patients, and were positively correlated with the severity of APIP ( MD values were 0.99, 65.97, 1.33, 6.44, 95% CI values were 0.03-1.96, 0.59-2.08, 23.43-108.50, 4.49-8.39, P values were 0.04, 0.0005, 0.002, <0.001). The levels of blood calcium and serum albumin were lower than those of mild patients, and were negatively correlated with the severity of APIP (MD values were -0.37, -5.93, 95% CI values were -0.50--0.24, -9.11--2.75, P values were <0.001, 0.003).
ConclusionsAcute pancreatitis can occur in all stages of pregnancy. Early pregnancy is mainly mild, and severe cases are more common in late pregnancy. Hypertriglyceridemic pancreatitis progresses rapidly, and tends to become more severe in China.
Key words:
Pancreatitis; Pregnancy; Risk factors; Meta-analysis
Contributor Information
Xiong Yuling
Department of Gastroenterology, Fengdu County People′s Hospital of Chongqing, Chongqing 408200, China
Tian Yue
Department of Gastroenterology, Fengdu County People′s Hospital of Chongqing, Chongqing 408200, China
Li Shan
Department of Gastroenterology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Yang Jing
Department of Gastroenterology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Gao Qing
Department of Gastroenterology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
