Objective To explore blocking of maternal-fetal transmission of syphilis in pregnancy and nursing care.Methods By retrospectively analyzing 108 cases,collected from January 2005 to October 2007,of blocking matemal-fetal transmission data among pregnant women infected with syphilis.Pregnancy outcome and prognosis status were compared between those under therapy and those were not. Results Average gestational week was( 38.22 ± 1.795 ) weeks,5 patients had premature delivery,accounting for 4.63％ ; Fullterm rate in treatment group was 98.51％ and 90.24％ in untreatment group,and the difference was not statistically significant ( x2 =2.29,P ＞ 0.05 ) ; Infants with congenital syphilis in treatment group was 4.48％ and less than 29.27％ in the untreatment group,and the difference was significant ( x2 =13.07,P ＜ 0.01 ) ;Those pregnant women,who did not receive standard treatment and the infant was diagnosed as congenital syphilis,were treated with anti-syphilitic therapy,and 79.63％ of RPR was negative within one year,79.41％ of TPPA was negative within 18 months,and all the other turned negative in 2 -3 years.Conclusions Reinforcing health care and supervision during gestation and evaluating pregnant women syphilis infection and treatment condition in time could prevent them from cross-infection and insure the healthy growth of children.