Objective To observe cefpirome's curative effects on pseudomonas aeruginosa pneumonia(PAP).Methods Ninety patients were randomly divided into two groups,study group(n =52)and control group(n = 38).In study group,these patients took cefpirome in the whole course;control group patients began to take ceftazidime 1-2 g,intravenous injection 2-3 times each day.Both groups also took amikacin during the course of treatment(14-21 days).Observe the efficiency rate,the cure rate,the rate of bacteriological elimination and the adverse reaction rate.Results The efficiency rate,the cure rate,the rate of bacteriological elimination and the adverse reaction rate were 92.3%,82.7%,90.4% and 9.6% in study group while in control group these were 84.2%,65.8%,68.4% and 10.5% respectively.There existed significant differences between them in the efficiency rate and the rate of bacteriological elimination(P＜0.05)while few obvious distinctions were found in other aspects(P＞0.05).Conclusions The drug therapeutic choice of cefpirome in patients together with amikacin for three weeks is safe and effective on PAP,which is better than ceftazidime.