Objective To study the efficacy and safety of lomerizine hydrochloride for treating migraine.Methods Fifty patients with migraine were randomly divided into lomerizine hydrochloride group (group A,25 cases) and control group (group B,25 cases),and the patients were treated with lomerizine hydrochloride or placebo orally respectively.The treatment were 12 weeks.The frequency of migraine attacks as the main assessment indicators,and attack duration,extent,accompanied by symptoms and headache composite score for secondary assessmentindicators,and recorded adverse reactions.Results ① The 4,8,12 and 16 weeks after treatment,the headache attack frequency,headache duration,headache extent,associated symptom and headache composite in group A were decreased significantly compared with group B (P all ＜0.01).②The total effective rates of group A and group B were 96.0％ and 16.0％ respectively (P ＜ 0.01).No serious adverse reaction occured in both groups.Conclusions Lomerizine hydrochloride is effective and safe for preventive treatment of migraine and there is still a certain period of time effect after stop medication.