To analyze treatment outcome and prognostic factors of children with acute lymphoblastic leukemia (ALL).

The clinical data and outcome of 176 pediatric ALL patients were collected, the clinical characteristics, genetic features, therapeutic response, prognosis and prognostic factors were studied retrospectively. Univariate analysis and Log-rank test were used to analyze the prognostic factors.

Among 176 patients, 143 cases got complete induction therapy, complete remission rate was 95.8%, and 5-year event free survival rate was 78.2%. Univariate analysis of prognostic factors: primary white blood cell (WBC) count ≥50×10⁹/L, age of onset ≥10-year old, T-ALL, had adverse reaction of prednisone, bone marrow in M2/3 stage after 15 days of induction, minimal residual disease (MRD) ≥10^-3 after 33 days of treatment, MRD≥10^-4 after 3 months of treatment, BCR/ABL gene positive and high-risk grade were related factors of poor prognosis. Multivariate COX regression analysis showed that T-ALL, bone marrow examination after 15 days of induction, MRD after 3 months of treatment, the risk grade were independent prognostic factors.

Children with ALL, especially non-high-risk patients, could obtain high CR rate and long-term survival by chemotherapy. T-ALL, bone marrow examintion after 15 days of induction for bone, 3 months MRD, and risk grade were independent prognostic factors.

Acute lymphoblastic leukemia; Children; Prognostic factors