Tianran Chen, Qiang Jin, Linghua Wei, Yabin Chen, Guangbo Ge, Wenzhi Guo
Abstract
Protease-activated receptor 1 (PAR1) is a subfamily of the G protein-coupled receptors, which is mainly distributed in the circulatory, nervous and digestive systems. PAR1 is mainly involved in hemostasis, memory formation, synaptic plasticity as well as gastrointestinal motility and secretion. With further research in recent years, it was found that PAR1 played a key role in development and progress of cardiovascular, neurological, neoplastic inflammatory diseases. Lucubrating the dynamic changes and molecular mechanisms of PAR1 in the development of diseases and designing specific drugs based on PAR1 is of great significance for the diagnosis and treatment of PAR1-related diseases. This article systematically reviews the structure, distribution characteristics, biological functions of PAR1 and its role in the development of the disease, intended to provide researchers in the field of medicine with a deeper understanding of PAR1 in the development of diseases, so as to provide new ideas for the treatment of PAR1 related diseases.
Key words:
Protease-activated receptor 1; Nervous system; Circulatory system; Inflammation; Tumor
Contributor Information
Tianran Chen
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou Key Laboratory of Hepatobiliary &
Pancreatic Diseases and Organ Transplantation, Open and Key Laboratory of Hepatobiliary &
Pancreatic Surgery and Digestive Organ Transplantation of Henan Universities, Zhengzhou 450001, China
Qiang Jin
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou Key Laboratory of Hepatobiliary &
Pancreatic Diseases and Organ Transplantation, Open and Key Laboratory of Hepatobiliary &
Pancreatic Surgery and Digestive Organ Transplantation of Henan Universities, Zhengzhou 450001, China
Cross Science Research Institute of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Linghua Wei
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou Key Laboratory of Hepatobiliary &
Pancreatic Diseases and Organ Transplantation, Open and Key Laboratory of Hepatobiliary &
Pancreatic Surgery and Digestive Organ Transplantation of Henan Universities, Zhengzhou 450001, China
Yabin Chen
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou Key Laboratory of Hepatobiliary &
Pancreatic Diseases and Organ Transplantation, Open and Key Laboratory of Hepatobiliary &
Pancreatic Surgery and Digestive Organ Transplantation of Henan Universities, Zhengzhou 450001, China
Guangbo Ge
Cross Science Research Institute of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Wenzhi Guo
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou Key Laboratory of Hepatobiliary &
Pancreatic Diseases and Organ Transplantation, Open and Key Laboratory of Hepatobiliary &
Pancreatic Surgery and Digestive Organ Transplantation of Henan Universities, Zhengzhou 450001, China
