Original Article
Value of combined detection of serum CA125, AFP, CA199, CEA and HE4 in diagnosis of ovarian neoplasms and its clinical stage
Liu Yi, Jiao Yunzhuan, Xiao Weiqiang, Liu Min
Published 2021-04-25
Cite as Chin J Pract Med, 2021, 48(8): 27-30. DOI: 10.3760/cma.j.cn115689-20201024-05029
Abstract
ObjectiveTo investigate the value of combined detection of serum carbohydrate antigen 125 (CA125), alpha fetoprotein (AFP), carbohydrate antigen 199 (CA199), carcinoembryonic antigen (CEA), and human epididymis protein-4 (HE4) in diagnosis of ovarian neoplasms and its clinical stage.
MethodsEighty-six patients with ovarian neoplasms (ovarian neoplasms group) and 82 patients with benign ovarian tumor (benign lesion group) admitted to Maternal and Child Health Care Hospital of Zhengzhou from January 2016 to December 2019 were selected. Blood samples were collected to detect the levels of serum CA125, AFP, CA199, CEA, and HE4, and the differences of detection indicators were compared between the two groups, and the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of the above serum indicators on ovarian neoplasms and its clinical staging.
ResultsThe levels of serum CA125, AFP, CA199, and HE4 in ovarian neoplasms group were significantly higher than those in benign lesion group (P<0.05). There was no statistically significant difference in the CEA level compared with that in benign lesion group (P>0.05). The levels of serum CA125, AFP, CA199, and HE4 of patients with Federation Internationale of Gynecologie and Obstetrigue (FIGO) pathological stage III to IV ovarian neoplasms were significantly higher than those of patients with stage I to II (P<0.05). There was no statistical difference in the CEA level compared with that of patients with stage I to II (P>0.05). Single detection of serum CA125 or HE4 had high diagnostic efficacy of Ovarian Neoplasms and stage III to IV, and the combined detection of serum CA125, AFP, CA199, CEA and HE4 could further improve the diagnostic efficacy of ovarian neoplasms and clinical staging (area under the curve=0.976, 0.948, 95%CI 0.000-1.000 and 0.000-1.000, P<0.05, sensitivities of 93.02% and 90.70%, specificities of 95.12% and 87.80%).
ConclusionsSerum CA125 and HE4 alone have good diagnostic efficacy in the diagnosis of ovarian neoplasms and its clinical staging. The combined detection of serum CA125, AFP, CA199, CEA and HE4 can further improve the diagnostic efficacy in the diagnosis of ovarian neoplasms and its clinical stage.
Key words:
Ovarian neoplasms; Carbohydrate antigen 125; Alpha fetoprotein; Carbohydrate antigen 199; Carcinoembryonic antigen; Human epididymis protein-4
Contributor Information
Liu Yi
Department of Reproductive Genetics, Maternal and Child Health Care Hospital of Zhengzhou, Zhengzhou 450012, China
Jiao Yunzhuan
Department of Clinical Laboratory, Zhengzhou Third People’s Hospital, Zhengzhou 450000, China
Xiao Weiqiang
Department of Clinical Laboratory, Cancer Hospital of Henan Province, Zhengzhou 450000, China
Liu Min
Department of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Zhengzhou, Zhengzhou 450012, China
