Drug Application
Clinical efficacy of labetalol combined with low-dose aspirin in treatment of preeclampsia
Guo Yingying, Zhang Kai, Liu Qiujin
Published 2021-12-25
Cite as Chin J Pract Med, 2021, 48(24): 82-85. DOI: 10.3760/cma.j.cn115689-20210927-03298
Abstract
ObjectiveTo observe the effect of labetalol combined with low-dose aspirin in the treatment of preeclampsia (PE).
MethodsEighty-six eligible patients with PE diagnosed by the Third Affiliated Hospital of Zhengzhou University from January 2019 to December 2019 were prospectively selected, they were divided into control group and observation group by random number table method, with 43 cases in each group. The control group was treated with routine treatment combined with labetalol, and the observation group was treated with low-dose aspirin on the basis of the control group, the effect was evaluated at 2 weeks of treatment. Blood pressure and 24-hour urinary protein levels of the two groups were evaluated and compared before treatment and 2 weeks after treatment; the coagulation function including prothrombin time (PT), activated partial prothrombin time (APTT), thrombin time (TT), fibrinogen (FIB), D-Dimer (D-D) of the two groups were evaluated and compared at each time point; the adverse pregnancy outcomes were recorded and compared between the two groups; during the treatment, the adverse reactions of the two groups were recorded.
ResultsAfter 2 weeks of treatment, the diastolic blood pressure, systolic blood pressure and 24-hour urinary protein levels in both groups were decreased than those before treatment, and those in the observation group were lower than those in the control group (P<0.05); the levels of PT, APTT and TT in both groups were all increased compared with those before treatment, while the levels of FIB and D-D were decreased compared with those before treatment, the levels of PT, APTT and TT in the observation group were higher than those in the control group, while the levels of FIB and D-D in the observation group were lower than those in the control group (P<0.05); the total incidence of adverse pregnancy outcomes in the observation group was lower than those in the control group (P<0.05); the incidence of adverse reactions was compared between the two groups(P>0.05).
ConclusionsLabetalol combined with low-dose aspirin is more conducive to improve blood pressure and 24-hour urinary protein level in the application of PE patients, it is more helpful to promote the recovery of coagulation function of patients and reduce the risk of adverse pregnancy outcomes, and will not increase the incidence of adverse reactions, and it is safe and reliable.
Key words:
Preeclampsia; Labetalol; Aspirin; Low dose
Contributor Information
Guo Yingying
Department of Intensive Care, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Zhang Kai
Department of Intensive Care, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Liu Qiujin
Department of Intensive Care, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
