Drug Application
Therapeutic effects of different bismuth containing quadruple therapies on Hp positive chronic atrophic gastritis
Wang Jing, Zhang Xiaolei, Yu Yulin
Published 2022-01-10
Cite as Chin J Pract Med, 2022, 49(1): 102-105. DOI: 10.3760/cma.j.cn115689-20210828-02852
Abstract
ObjectiveTo investigate the clinical effects of different bismuth containing quadruple therapies in the treatment of Helicobacter pylori (Hp) positive chronic atrophic gastritis.
MethodsA total of 96 patients with chronic atrophic gastritis treated in Weihai Third Municipal Hospital from May 2018 to May 2020 were selected as the research objects, and they were divided into observation group (48 cases) and control group (48 cases) by tossing coin. The control group was treated with bismuth containing quadruple therapy (levofloxacin tablets, amoxicillin capsules, rabeprazole sodium enteric coated tablets, compound bismuth aluminate tablets) for 2 courses; while the observation group had prolonged admission course of rabeprazole sodium enteric coated tablets and compound bismuth aluminate tablets based on the treatment of the control group. The serum indexes, including serum gastrin and procalcitonin (PCT), Hp clearance rate, and recurrence rate were compared between the two groups.
ResultsAfter treatment, the total effective rate of the observation group was 95.83%(46/48), higher than 81.25%(39/48) of the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of gastrin and PCT in the two groups were lower than before treatment, and the levels of gastrin and PCT in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the Hp clearance rate of the observation group (95.83%, 46/48) was higher than that of the control group (81.25%, 39/48), and the difference was statistically significant (P<0.05). There was no significant difference in recurrence rate between the two groups (P>0.05).
ConclusionsProlonging the course of PPI and bismuth in bismuth containing quadruple therapy is helpful to improve the therapeutic effect of chronic atrophic gastritis, increase the Hp clearance rate, improve the levels of gastrin and PCT, and reduce the recurrence rate to a certain extent.
Key words:
Chronic atrophic gastritis; Helicobacter pylori; Bismuth; Quadruple therapy; Clearance rate of Helicobacter pylori
Contributor Information
Wang Jing
Department of Pharmacy, Weihai Third Municipal Hospital, Weihai 264200, China
Zhang Xiaolei
Department of Hospital Information, Weihai Third Municipal Hospital, Weihai 264200, China
Yu Yulin
Department of Gastroenterology, Weihai Third Municipal Hospital, Weihai 264200, China
