Original Article
Effect of high flux hemodialysis combined with hemoperfusion on calcium and phosphorus metabolism, AGEs and ICAM-1 levels in patients with uremia
Li Hui, Niu Cong, Zhang Wei, Hu Chunyan, Liu Jianlin
Published 2022-09-25
Cite as Chin J Pract Med, 2022, 49(18): 46-49. DOI: 10.3760/cma.j.cn115689-20220620-02630
Abstract
ObjectiveTo analyze the clinical effect of high flux hemodialysis combined with hemoperfusion in the treatment of uremia.
MethodsA total of 92 patients with uremia treated in First Affiliated Hospital of Henan University from February 2018 to October 2020 were selected, and they were divided into combined group and dialysis group by random number table method, with 46 case in group. The dialysis group was treated by high flux hemodialysis, and the combined group was treated by hemoperfusion based on the treatment of the dialysis group. The curative effect, renal function assessed by blood urea nitrogen (BUN) and β2 microglobulin (β2-MG), calcium and phosphorus metabolism (blood calcium and phosphorus), immune function assessed by T lymphocyte subsets cluster of differentiation 3+ (CD3+ ) and cluster of differentiation 8+ (CD8+ ), vascular endothelial function assessed by advanced glycation end products (AGEs) and intercellular cell adhesion molecule-1 (ICAM-1) before and after treatment were compared between the two groups.
ResultsThe total effective rate of the combined group (86.96%, 40/46) was higher than that of the dialysis group (67.39%, 31/46), P<0.05. After treatment, the levels of BUN and β2-MG of the combined group were lower than those of the dialysis group (P<0.05). After treatment, the serum calcium of the combined group was higher than that of the dialysis group, and the blood phosphorus was lower than that of the dialysis group (P<0.05). After treatment, the level of CD3+ of the combined group was higher than that of the dialysis group, and the level of CD8+ was lower than that of the dialysis group (P<0.05). After treatment, the levels of AGEs and ICAM-1 of the combined group were lower than those of the dialysis group (P<0.05).
ConclusionsHigh flux hemodialysis combined with hemoperfusion is effective in the treatment of uremia, which can regulate calcium and phosphorus metabolism and immune status, and improve renal function and vascular endothelial function.
Key words:
Uremia; Hemoperfusion; High flux hemodialysis; Renal function; Calcium and phosphorus metabolism; Vascular endothelial function
Contributor Information
Li Hui
Department of Nephrology, First Affiliated Hospital of Henan University, Kaifeng 475000, China
Niu Cong
Department of Nephrology, First Affiliated Hospital of Henan University, Kaifeng 475000, China
Zhang Wei
Department of Nephrology, First Affiliated Hospital of Henan University, Kaifeng 475000, China
Hu Chunyan
Department of Nephrology, First Affiliated Hospital of Henan University, Kaifeng 475000, China
Liu Jianlin
Department of Nephrology, First Affiliated Hospital of Henan University, Kaifeng 475000, China
