To investigate the clinical characteristics of adverse reactions caused by antibiotics.

The clinical data of 800 cases of adverse reactions to antibiotics recorded in Zhumadian First People’s Hospital from December 2019 to December 2021 were retrospectively analyzed. The common adverse reactions, types of antibiotics, and age ranges with high incidence of adverse reactions were collected.

The incidence of adverse reactions in the population with age of 51 to 76 years (45.63%, 365/800) was the highest, which was significantly higher than that in the population with age of 16 to 32 years (23.62%, 189/800) and with age of 33 to 50 years (30.75%, 246/800), P<0.05. The most common antibiotic with adverse reactions was levofloxacin (161 cases), followed by cefotaxime (132 cases), ceftriaxone (102 episodes), and amoxicillin (82 cases). The most common adverse reaction of antibiotics was nausea (127 cases), followed by rash (113 cases) and pruritus (104 cases).

As the age of the patients increases, the incidence of adverse reactions caused by antibiotics increases. The commonly used antibiotics with adverse reactions are levofloxacin, cefotaxime, and amoxicillin; while the most common adverse reactions are nausea, rash and itching. It is necessary to continuously improve the drug application system, standardize the drug use, and rationally use antibiotics in clinical.

Anti-bacterial agents; Adverse reactions; Clinical characteristic