Original Article
A comparative study on the predictive value of new simplified insulin resistance assessment indicators in identifying glucose metabolism disturbance
Li Rongrong, Shi Xiaodong, Chen Wei
Published 2022-01-20
Cite as Chin J Diabetes Mellitus, 2022, 14(1): 56-62. DOI: 10.3760/cma.j.cn115791-20210805-00428
Abstract
ObjectiveTo compare and screen for new simplified insulin resistance (IR) assessment indicators with high diagnostic efficacy.
MethodsWe included consecutive 136 healthy participants without type 2 diabetes or impaired glucose tolerance from October 2019 to October 2020 in Peking Union Medical College Hospital, and collected their demographic data and clinical parameters, including the height, weight, waist circumference (WC), fasting plasma glucose (FPG), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), glycated hemoglobin A1c (HbA1c), fasting insulin (FINS) with body mass index (BMI) and homeostasis model assessment of insulin resistance (HOMA-IR) calculated. Some new simplified IR assessment indicators were calculated, including triglyceride/HDL-C ratio, triglyceride glucose (TyG) index, TyG-BMI index, TyG-WC, visceral adiposity index (VAI), lipid accumulation product (LAP), metabolic score for IR (METS-IR), and estimate of insulin sensitivity (e-IS). The subjects were divided into normal weight group (BMI<24 kg/m2) and overweight and obesity group (24 kg/m2≤BMI<30 kg/m2). The clinical parameters and the new simplified IR assessment indicators were compared between groups with t-test. Correlation between the HOMA-IR and the new simplified IR assessment indicators was analyzed with the Pearson correlation analysis. With HOMA-IR as the reference standard, the receiver operating characteristic curve was used to analyze the diagnostic efficacy of different simplified IR assessment indicators, with the area under the curve (AUC) calculated.
ResultsTotal 136 participants were included, all aged (43.80±10.52) years with 45 men and 91 women. Forty participants were classified into the normal weight group, while the other 96 participants fell into the overweight and obesity group. Compared with the normal weight group, the waist circumference, HOMA-IR, TG/HDL-C ratio, TyG index, TyG-BMI, TyG-WC, VAI, LAP, and METS-IR of subjects in the overweight and obese group were significantly increased (all P<0.05). For all subjects, FPG, TG/HDL-C ratio, TyG index, TyG-BMI, TyG-WC, VAI, LAP, and METS-IR were positively correlated with HOMA-IR (r=0.409-0.478), whereas e-IS and HOMA-IR were negatively correlated (r=-0.290). TyG index, TyG-BMI, LAP, METS-IR had high AUC (0.701-0.736).
ConclusionsThe TyG, TyG-BMI, LAP and METS-IR have certain predictive value in evaluating insulin sensitivity in the Chinese adult population.
Key words:
Glucose metabolism disorders; Insulin resistance; Triglyceride glucose index; Triglyceride-body mass index; Lipid accumulation product; Metabolic score for insulin resistance
Contributor Information
Li Rongrong
Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, Department of Clinical Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Shi Xiaodong
Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, Department of Clinical Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Chen Wei
Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, Department of Clinical Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
