Original Article
Analysis of differences in the changes of blood vessel and lesion area in patients with different types of diabetic macular edema
Ju Chaojuan, Liang Xiaoli, Zhao Lina, Shi Xiaonan, Wang Lina, Zhang Xin
Published 2023-07-20
Cite as Chin J Diabetes Mellitus, 2023, 15(7): 630-634. DOI: 10.3760/cma.j.cn115791-20221230-00740
Abstract
ObjectiveTo analyze the changes in blood vessel and lesion area in different types of diabetic macular edema (DME).
MethodsA total of 196 patients with DME who were treated in First Hospital of Hebei Medical University from January 2018 to January 2021 were selected as the observation objects. They were divided into simple diffuse DME group [without serous retinal detachment (SRD), 126 cases] and observation group according to SRD type DME group (combined SRD, 192 cases). General data such as age, sex, duration of diabetes and creatinine were compared between the two groups. Routine eye examinations and optical coherence tomography angiography were performed in both groups. The macular foveal retinal thickness (CST), and subfoveal choroidal thickness (SFCT) of the fovea were compared between the two groups. The area of fovea avascular zone (FAZ) and the level of deep-superficial flow ratio (DSFR) were compared between the two groups. Independent sample t-test was used to compare the two groups. Multivariate logistic regression was used to analyze the influencing factors of DME patients with SRD.
ResultsCompared with the simple diffuse DME group, the CST in the SRD-type DME group [(485.63±18.63) μm vs. (405.61±25.36) μm, t=32.395, P<0.001] and SFCT levels [(295.46±51.16) μm vs. (274.16±52.98) μm, t=3.581, P<0.001] were increased, DSFR level (1.10±0.05 vs. 1.16±0.12, t=6.164, P<0.001) and FAZ area [(0.31±0.16) mm2vs. (0.38±0.12) mm2, t=4.196, P<0.001] were decreased, and the differences were statistically significant. Multivariate logistic regression analysis showed that SFCT, DSFR and FAZ area were independent risk factors for DME patients with SRD (OR=1.905, P=0.005; OR=0.452, P=0.001; OR=0.658, P=0.012).
ConclusionThere were differences in SFCT, DSFR and FAZ area in patients with different types of DME, which were the risk factors for SRD in DME patients.
Key words:
Diabetes mellitus; Macular edema; Blood flow density; Deep-superficial flow ratio; Foveal avascular zone area
Contributor Information
Ju Chaojuan
Department of Ophthalmology, First Hospital of Hebei Medical University, Shijiazhuang 050031, China
Liang Xiaoli
Department of Ophthalmology, First Hospital of Hebei Medical University, Shijiazhuang 050031, China
Zhao Lina
Department of Ophthalmology, First Hospital of Hebei Medical University, Shijiazhuang 050031, China
Shi Xiaonan
Department of Ophthalmology, First Hospital of Hebei Medical University, Shijiazhuang 050031, China
Wang Lina
Department of Endocrinology, First Hospital of Hebei Medical University, Shijiazhuang 050031, China
Zhang Xin
Department of Ophthalmology, First Hospital of Hebei Medical University, Shijiazhuang 050031, China
