Specific Original Articles on Thyroid and Parathyroid Disease
Effect of glucocorticoids on perioperative patients with thyroid cancer
Qingjun Zhang, Yongbo Wang, Qungang Chang, Detao Yin
Published 2019-08-25
Cite as Chin J Endocr Surg, 2019, 13(4): 289-292. DOI: 10.3760/cma.j.issn.1674-6090.2019.04.006
Abstract
ObjectiveTo investigate the application effect of glucocorticoids on perioperative period of complicated thyroid cancer surgery.
MethodsAll patients were from Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University. A total of 373 patients with thyroid surgery longer than 3 hours from Jan. 2017 to Dec. 2017 were as the control group. 386 patients with thyroid surgery longer than 3 hours from Jan. 2018 to Dec. 2018 were included in the observation group. Patients in the control group were not treated with glucocorticoids during perioperative period, and patients in the observation group were treated with glucocorticoids during perioperative period. Several factors were compared between the two groups, including postoperative drain removal time, postoperative hospitalization time, postoperative complication rate, the incidence of postoperative infection and delayed wound healing.
ResultsThe postoperative drain removal time [ (2.5±0.42) vs (3.2±0.63) , t=25.72, P<0.001) ] and the postoperative hospitalization time[ (3.6±0.57) vs (4.8±0.71) , t=18.07, P<0.001) ] in the observation group was shorter than in the control group. The incidence of complications in the observation group was lower than that in the control group, such as postoperative coarse respiratory sounds (3.1% vs 6.7%, χ2=4.790, P=0.029) , mild to moderate dyspnea (1.0% vs 3.2%, χ2=4.191, P=0.041) , cough (8.3% vs 14.2%, χ2=5.366, P=0.021) , sore throat (4.9% vs 9.4%, χ2=4.952, P=0.026) , headache (8.8% vs 11.5%, χ2=4.392, P=0.036) and nausea (3.6% vs 8.6%, χ2=7.235, P=0.007) , however, the incidence of hoarseness between the two groups was statistically significant (1.6% vs 2.1%, χ2=0.352, P=0.553) . There was no significant difference in the incidence of postoperative infection (2 cases vs 1 case, χ2=0.299, P=0.585) or delayed wound healing (3 cases vs 3 cases, χ2=0.002, P=0.964) between the two groups.
ConclusionThe application of glucocorticoids in patients with complicated thyroid cancer surgery can effectively reduce the incidence of complications and shorten the hospitalization time of patients.
Key words:
Thyroid cancer surgery; Perioperative period; Glucocorticoids
Contributor Information
Qingjun Zhang
Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Yongbo Wang
Qungang Chang
Detao Yin
