Specific Original Article on Thyroid Disease
Diagnosis and treatment of primary thyroid lymphoma: a single center analysis
Tian Wuguo, Hao Shuai, Ma Qiang, Li Xiaoguang, Wang Lingli, Zhao Jianjie, Luo Donglin
Published 2020-08-25
Cite as Chin J Endocr Surg, 2020, 14(4): 295-300. DOI: 10.3760/cma.j.issn.115807-20191104-00214
Abstract
ObjectiveTo summarize the experience of diagnosis and treatment of primary thyroid lymphoma (PTL) and improve the level of diagnosis and treatment.
MethodsThe clinical and pathological data of 19 patients with PTL admitted to the Department of Breast and Thyroid Surgery, Daping Hospital, Army Medical University From Mar. 2000 to Jul. 2019 were retrospectively reviewed.
Resultsamong the 19 PTL patients, 4 were male and 15 were female, with an average age of 69 years (51-88 years) . 15 cases showed rapid enlargement of neck mass, 9 cases with swallowing obstruction, 7 cases with hoarseness and 5 cases with dyspnea. 13 cases were diagnosed by intervention, the other 6 cases were diagnosed by biopsy. There were 1 case of Hodgkin’s lymphoma and 18 cases of non Hodgkin’s lymphoma, including 13 cases of diffuse large B cell lymphoma and 4 cases of mucosa associated lymphoid tissue lymphoma. 12 cases received chemotherapy and 1 case received radiotherapy. The median follow-up period was 28 months (0-88 months) , 5 cases were lost, 6 cases died, 3 cases died of recurrence and spread of lymphoma, 3 cases died of others.
ConclusionsPTL is more likely to occur in the elderly women, which is characterized by sudden enlargement of cervical mass and its related compression symptoms. The diagnosis can be confirmed by coarse needle biopsy or surgical intervention. PTL needs comprehensive treatment including surgery, chemotherapy and targeted treatment.
Key words:
Thyroid tumor; Primary lymphoma
Contributor Information
Tian Wuguo
Department of Breast and Thyroid Surgery, Daping Hospital, Army Military Medical University, Chongqing 400016, China
Hao Shuai
Department of Breast and Thyroid Surgery, Daping Hospital, Army Military Medical University, Chongqing 400016, China
Ma Qiang
Department of Pathology, Daping Hospital, Army Military Medical University, Chongqing 400016, China
Li Xiaoguang
Department of Medical Imaging, Daping Hospital, Army Military Medical University, Chongqing 400016, China
Wang Lingli
Department of Breast and Thyroid Surgery, Daping Hospital, Army Military Medical University, Chongqing 400016, China
Zhao Jianjie
Department of Breast and Thyroid Surgery, Daping Hospital, Army Military Medical University, Chongqing 400016, China
Luo Donglin
Department of Breast and Thyroid Surgery, Daping Hospital, Army Military Medical University, Chongqing 400016, China
