Specific Original Article on Gastrointestinal Disease
Prognosis analysis of lymphovascular invasion and other clinicopathological risk factors
Cui Weihao, Hu Jinchen, Wang Xixun, Cai Li, Zhang Yifei, Zhao Dawei, Liu Chuanxu, Jiang Lixin
Published 2020-12-25
Cite as Chin J Endocr Surg, 2020, 14(6): 450-454. DOI: 10.3760/cma.j.cn.115807-20200625-00200
Abstract
ObjectiveTo analyze the connection between lymphovascular invasion (LVI) and other clinicopathological factors and its effect on the prognosis of gastric cancer.
MethodsClinicopathological data of 621 patients were retrospectively analyzed. According to the presence of LVI, the patients were divided into two groups: LVI positive (LVI+) group and LVI negative (LVI-) group. The 5-year cumulative survival rate of the two groups were compared. Meanwhile the connection between LVI and other clinicopathological factors and its effect on the prognosis of gastric cancer were analyzed.
ResultsThe incidence of LVI was 31.7% (197 cases) among the 621 patients. Binary logistic regression analysis showed significant correlation between LVI and the degree of tumor differentiation, depth of invasion and the presence of lymph node metastasis (P<0.01) . Trendχ2 test showed that there was linear correlation between degree of tumor differentiation, depth of invasion, lymph node metastasis and the positive rate of LVI in gastric cancer (P<0.01) , and the correlation between lymph node metastasis and LVI was more significant (r=0.387) . The 5-year cumulative survival rate in the LVI+ group was significantly lower than that in the LVI- group, and the difference was statistically significant (46.7% vs 73.3%; P<0.01) . A multivariate analysis also identified age, diameter of tumor, TNM stage and LVI as the independent prognostic factors for patients with gastric cancer (P<0.05) . In further stratified analysis, the 5-year cumulative survival rate of the LVI+ group was significantly lower than that of LVI- group in patients at stage Ⅲ (36.1% vs 51.4%;P<0.05) .
ConclusionsLVI is an independent indicator for poor prognosis of gastric cancer. The combination of LVI and TNM staging could predict the prognosis of patients with gastric cancer more accurately.
Key words:
Stomach neoplasms; Lymphovascular invasion; Neoplasm staging
Contributor Information
Cui Weihao
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Hu Jinchen
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Wang Xixun
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Cai Li
Department of Pathology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Zhang Yifei
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Zhao Dawei
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Liu Chuanxu
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Jiang Lixin
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
