Original Article
Prognosis analysis and relationship between perineural invasion and gastric cancer and other clinicopathological risk factors
Liu Chuanxu, Wang Xixun, Hu Jinchen, Yao Zengwu, Cui Weihao, Cai Li, Jiang Lixin
Published 2022-04-25
Cite as Chin J Endocr Surg, 2022, 16(2): 216-220. DOI: 10.3760/cma.j.cn.115807-20210210-00048
Abstract
ObjectiveTo analyze the relationship between perineural invasion and other clinicopathological factors and its effect on the prognosis of gastric cancer.
MethodsThe clinicopathological data of 665 patients with gastric cancer were retrospectively analyzed. According to the presence of perineural invasion, the patients were divided into perineural invasion positive group and perineural invasion negative group. The relationship between perineural invasion and other clinicopathological factors and its effect on the prognosis of gastric cancer were analyzed. After eliminating the potential confusion bias between the two groups by propensity score matching (PSM) , the differences of 5-year cumulative survival rate between the two groups of gastric cancer patients were compared.
ResultsThe incidence of perineural invasion was 17.0% (113 cases) . The binary logistic regression analysis showed that the depth of tumor invasion and vascular tumor thrombus were independent factors influencing the occurrence of gastric cancer perineural invasion (all P<0.001) . Univariate analysis showed that age (>60 years) , tumor diameter (>4 cm) , borrmann classification, depth of invasion, lymph node metastasis, TNM stage, degree of differentiation, vascular tumor thrombus, perineural invasion, tumor nodule, tumor site, resection site, and surgical operation were the influencing factors for the prognosis of patients with gastric cancer (P<0.05) , but multivariate analysis showed that age (>60 years) , tumor diameter (>4cm) , depth of invasion, lymph node metastasis, and positive vascular tumor thrombi were independent risk factors affecting the prognosis of gastric cancer patients (P<0.05) .However, perineural invasion cannot be an independent factor influencing the poor prognosis of gastric cancer in a multivariate analysis. Survival analysis was performed after propensity matching scores, and it was found that there was no statistically significant difference in the five-year survival rate between the perineural invasion positive group and the perineural invasion negative group (34.6% vs 43.0%;χ2=1.713;P=0.191) ,and there was no significant difference in the survival curve analysis between the two.
ConclusionMost patients with gastric cancer of perineural invasion have poor prognosis, but perineural invasion cannot be an independent prognostic factor for the prognosis of gastric cancer.
Key words:
Stomach neoplasms; Perineural invasion; Prognosis; Neoplasm staging
Contributor Information
Liu Chuanxu
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Wang Xixun
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Hu Jinchen
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Yao Zengwu
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Cui Weihao
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Cai Li
Departmentof Pathology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Jiang Lixin
The First Department of Gastrointestinal Surgery, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
