Review
Research progress of heat shock protein 90 in breast cancer
Guo Maolin, Zheng Chao, Yu Lixiang, Liu Liyuan, Zhao Linfeng, Yu Zhigang
Published 2023-04-25
Cite as Chin J Endocr Surg, 2023, 17(2): 249-252. DOI: 10.3760/cma.j.cn.115807-20220811-00220
Abstract
Breast cancer has become the most common malignant tumor in the world. Heat shock protein 90 (HSP90) is a kind of molecular chaperone which can promote protein folding and maintain protein stability. HSP90 includes HSP90α, HSP90β, GRP94 and TRAP1 subtypes. Previous studies have found that the level of HSP90 is significantly increased in malignant tumors such as breast cancer, and is closely related to the occurrence and development of tumors. Meanwhile, the research on inhibitors targeting HSP90 has also attracted much attention. In this paper, we reviewed the expression of four HSP90 subtypes in breast cancer and their relationship with the clinicopathologic feature and prognosis of patients, discussed the research progress of specific inhibitors of HSP90 subtypes in breast cancer, and analyzed the application prospect of HSP90 as biomarkers for breast cancer prognosis monitoring and therapeutic targets.
Key words:
Heat shock protein 90; Breast cancer; Clinicopathologic feature; Prognosis; Inhibitors
Contributor Information
Guo Maolin
Department of Breast Surgery, the Second Hospital of Shandong University
Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University
Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan 250033, China
Zheng Chao
Department of Breast Surgery, the Second Hospital of Shandong University
Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University
Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan 250033, China
Yu Lixiang
Department of Breast Surgery, the Second Hospital of Shandong University
Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University
Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan 250033, China
Liu Liyuan
Department of Breast Surgery, the Second Hospital of Shandong University
Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University
Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan 250033, China
Zhao Linfeng
Department of Breast Surgery, the Second Hospital of Shandong University
Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University
Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan 250033, China
Yu Zhigang
Department of Breast Surgery, the Second Hospital of Shandong University
Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University
Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan 250033, China
