冯雪莹; 王青; 石中云; 尹晓妮; 高琳; 李慧; 周姝

doi:10.3760/cma.j.issn.1674-845X.2017.12.004

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年龄因素对成年人角膜厚度的影响

中华眼视光学与视觉科学杂志, 2017,19(12) : 727-731. DOI: 10.3760/cma.j.issn.1674-845X.2017.12.004

摘要

目的：

探讨不同年龄段成年人角膜厚度的差异。

方法：

横断面研究。选择2015年8-12月就诊于青岛大学附属医院眼科的近视及白内障患者300例（300眼）。按年龄分为3组：青年组96例，平均年龄（26.4±5.5）岁；中年组86例，平均年龄（62.1±6.8）岁；老年组118例，平均年龄（79.2±5.6）岁。应用Galilei眼前房分析系统测量各组的角膜厚度。对各组中央角膜厚度（CCT）、旁中央角膜厚度（PaCT）、周边角膜厚度（PeCT）及角膜最薄点厚度（TCT）等指标进行比较分析。采用单因素方差分析、Kruskal-WallisH秩和检验、Pearson相关分析及Spearman相关分析对数据进行分析。

结果：

3组间CCT、PaCT差异均无统计学意义。PeCT总体差异有统计学意义（H=39.12，P<0.001），且青年组PeCT均比中年组和老年组PeCT厚（P<0.05）。3组间TCT总体差异有统计学意义（H=31.63，P<0.001），且青年组TCT比中年组TCT厚（P=0.002），中年组TCT比老年组TCT厚（P=0.002）。在各组内，中年组PeCT与年龄呈负相关（r=-0.288，P=0.007），青年组、老年组的CCT、PaCT、PeCT、TCT与年龄均无相关性。对于总体，CCT、PaCT与年龄无相关性，而PeCT、TCT与年龄均呈负相关（r=-0.369、-0.343，P<0.001）。

结论：

成年人的CCT、PaCT不随年龄的变化而改变，PeCT、TCT随年龄增长有变薄的趋势。

引用本文: 冯雪莹, 王青, 石中云, 等. 年龄因素对成年人角膜厚度的影响 [J] . 中华眼视光学与视觉科学杂志, 2017, 19(12) : 727-731. DOI: 10.3760/cma.j.issn.1674-845X.2017.12.004.

参考文献导出: Endnote NoteExpress RefWorks NoteFirst 医学文献王

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版权归中华医学会所有。

未经授权，不得转载、摘编本刊文章，不得使用本刊的版式设计。

除非特别声明，本刊刊出的所有文章不代表中华医学会和本刊编委会的观点。

角膜是人眼屈光介质的重要组成部分，其屈光效力约相当于43 D的凸透镜。角膜厚度是角膜的形态参数之一。角膜厚度与多种因素如内眼手术^[1]、干眼症^[2]、糖尿病^[3,4]等有关。年龄也是角膜厚度的影响因素之一^{[5,6,7,8,9,10]}。而关于年龄与角膜厚度之间的关系，目前尚没有统一的意见。研究显示老年人角膜厚度明显变薄^[5]，中央角膜厚度（CCT）与年龄呈显著负相关^[6,7]。而有的研究结果得出相反结论，认为中老年人CCT比年轻人CCT厚，而周边角膜厚度与年龄呈负相关^[8]。有研究者认为50岁之前，CCT随年龄增长而降低；而50岁之后，男性CCT每年平均增厚约0.43 μｍ，女性CCT每年平均增厚0.13 μm^[9]。杨柳等^[10]将研究对象分为青年、中年和老年组，发现中年组平均角膜厚度较厚。为进一步明确角膜厚度随年龄的变化趋势，本研究对就诊于青岛大学附属医院眼科的患者眼部检查结果进行数据分析，现将结果报告如下。

贡献者信息

冯雪莹

266071　青岛大学

王青

266003　青岛大学附属医院眼科

石中云

266071　青岛大学

尹晓妮

266003　青岛大学附属医院眼科

高琳

266003　青岛大学附属医院眼科

李慧

266003　青岛大学附属医院眼科

周姝

266003　青岛大学附属医院眼科

通信作者

王青

266003　青岛大学附属医院眼科

Email：wangqing6836@sina.com

关键词

年龄因素; 中央角膜厚度; 旁中央角膜厚度; 周边角膜厚度; 角膜最薄点厚度;

基金项目

国家自然科学基金（81300790）

作者声明

作者贡献声明

冯雪莹：参与选题、设计，收集数据，进行资料的分析；撰写论文；根据编辑部的修改意见进行修改。王青：参与选题、设计、资料解释，修改论文中关键性结果、结论，根据编辑部的修改意见进行修改。石中云、尹晓妮、高琳、李慧、周姝：收集数据，进行资料的分析

利益冲突

利益冲突申明

本研究无任何利益冲突

历史

出版日期：2017-12-25

收稿日期：2017-06-22

本文编辑

吴飞盈

Original Article

Age-Related Changes in Corneal Thickness in Adults

Feng Xueying, Wang Qing, Shi Zhongyun, Yin Xiaoni, Gao Lin, Li Hui, Zhou Shu

Published 2017-12-25

Cite as Chin J Optom Ophthalmol Vis Sci, 2017, 19(12): 727-731. DOI: 10.3760/cma.j.issn.1674-845X.2017.12.004

Abstract

Objective:

To investigate adult age-related changes in corneal thickness.

Methods:

In this cross-sectional study, one eye in each of 300 myopia and cataract outpatients at the Affiliated Hospital of Qingdao University from August to December, 2015 was studied. The patients were divided into three groups: Young (21 to 45 years old, [mean ± standard deviation] 26.4 ± 5.5 years, 96 eyes); Middle-aged (46 to 70 years old, 62.1±6.8 years, 86 eyes); and Elder (71 to 92 years old, 79.2 ± 5.6 years, 118 eyes). The Galilei Dual Scheimpflug Analyzer was used to measure corneal pachymetry. Central corneal thickness (CCT) and paracentral corneal thickness (PaCT) were evaluated by analysis of variance, and peripheral corneal thickness (PeCT) and thinnest corneal thickness (TCT) were analyzed by Kruskal-Wallis H rank-sum test. The relationship between the variables and age were analyzed by Pearson correlation analysis and Spearman correlation analysis.

Results:

There were no significant differences among the three groups in CCT and PaCT. Among the three groups there were significant differences in PeCT (H=39.12, P<0.001). The PeCT of the Young Group was thicker than both the Middle-aged Group (P=0.017) and the Elder Group (P<0.001), but the difference in thickness between the Middle-aged and Elder Groups was not significant (P=0.193). For TCT, there were significant differences among the three groups (H=31.63, P<0.001). The TCT of the Young Group was thicker than both the Middle-aged Group (P=0.002) and the Elder Group (P<0.001), and the TCT of the Middle-aged Group was thicker than the Elder Group (P=0.002). PeCT was weakly correlated with age in the Middle-aged Group (r=-0.288, P=0.007). Other variables were not correlated with age in any of the groups. In general, CCT and PaCT were not correlated with age. In contrast, PeCT and TCT were negatively correlated with age (r=-0.369, -0.343, P<0.001).

Conclusions:

As people age, PeCT and TCT tend to get thinner, while CCT and PaCT do not change significantly.

Key words:

age factors; central corneal thickness; paracentral corneal thickness; peripheral corneal thickness; thinnest corneal thickness

Contributor Information

Feng Xueying

Qingdao University, Qingdao 266071, China

Wang Qing