Clinical Science
Long-term changes of corneal endothelial cells following Artisan phakic intraocular lens implantation
Daowei Qian, Haike Guo, Jin Zeng, Hongyang Zhang, Yongyi Niu
Published 2016-06-10
Cite as Chin J Exp Ophthalmol, 2016, 34(6): 541-544. DOI: 10.3760/cma.j.issn.2095-0160.2016.06.013
Abstract
BackgroundArtisan phakic intraocular lens (pIOL) implantation was demonstrated to be safe and effective for the correction of high myopia in short-term.However, long-term corneal endothelium status after operation should be concerned.
ObjectiveThis study was to investigate the long-term changes of corneal endothelial cell density (ECD) and morphology following Artisan pIOL implantation for the correction of high myopia.
MethodsFifty-one eyes of 27 patients who received Artisan PIOL implantation for high myopia from January 2005 to December 2008 were retrospectively analyzed.The central corneal ECDs were detected by corneal endothelial cell counter before surgery and 6 months and 1 year, 2, 3, 4, 5, 6 years after surgery, and the coefficient of variation (CV) and standard deviation (SD) of cellular area were evaluated.ECD loss rate with time lapse was calculated ([preoperative ECD-postoperative ECD]/preoperative ECD×100%).
ResultsSix years after surgery, there were 34 eyes with BCVA≥1.0, 14 eyes with BCVA higher than preoperative and 8 eyes with BCVA lower than preoperative.The mean intraocular pressure was (14.23±2.14)mmHg 6 years postoperative.The preoperative mean ECD was (3 184.05±233.55)/mm2, and the ECD was gradually reduced over time with the cell loss 2.34% in 6 months, 5.32% in 1 year, 6.32% in 2 years, 8.06% in 3 years, 12.59% in 4 years, 15.63% in 5 years and 19.49% in 6 years after operation.Before surgery, The mean CV of cellular area was 37.17±7.12, and the SD of cellular area was 118.77±21.39, and those 6 years after surgery were 32.24±4.62 and 125.60±18.49, respectively.The mean CV and SD of cellular area were significantly different among different time points (P=0.000, 0.036). Eight eyes with localized iris depigmentation, 6 eyes with IOL dyssymmetry, 3 eyes with transient high intraocular pressure and 2 eyes with Macular hemorrhage were obtained after surgery.
ConclusionsCorneal endothelial cells appear obvious changes in both number and morphology after Artisan pIOL implantation in high myopia.ECD is gradually reduced with time lapse, and the shape of the cells occur remodeling during 6-year fellow-up duration.Overall, endothelial specular microscopy is mandatory before and after surgery for a long term.
Key words:
Phakic; Intraocular lens; Cornea endothelial cell; High myopia
Contributor Information
Daowei Qian
Southern Medical University, Guangzhou 510515, China (now in Department of Ophthalmology, Pingshan New District Peoples Hospital of Shenzhen)
Haike Guo
Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Jin Zeng
Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Hongyang Zhang
Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Yongyi Niu
Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
