Investigative Science
Percentage of primary open angle glaucoma in retinal vein occlusion patients
Ke Xu, Lingling Wu, Zhizhong Ma, Yuling Liu, Fang Qian
Published 2016-06-10
Cite as Chin J Exp Ophthalmol, 2016, 34(6): 552-557. DOI: 10.3760/cma.j.issn.2095-0160.2016.06.016
Abstract
BackgroundResearches determined that the pathogenesis of retinal vein occlusion (RVO) is associated with primary open angle glaucoma (POAG) in Caucasian population.However, the relationship between RVO and POAG in Asian population is unclear.
ObjectiveThis study was to survey the percentage of POAG in RVO patients in China.
MethodsA prospective cross-sectional observational study based on hospital was performed.Three hundred and seventy five patients with newly diagnosed RVO by fluorescein fundus angiography (FFA) were consecutively enrolled in Peking University Third Hospital from October 2011 to May 2013, and gonioscopy was carried out in all the patients.Glaucoma was diagnosed according to the criteria of the International Society of Geographical and Epidemiological Ophthalmology (ISGEO). RVO was classified into central retinal vein occlusion (CRVO), hemicentral retinal vein occlusion (HRVO) and branch retinal vein occlusion (BRVO) based on fundus photograph and FFA, or classified into arteriovenous crossing RVO (AV-RVO), optic cup RVO(OC-RVO), optic nerve RVO without optical nerve head swelling (NONHS-RVO) and RVO with optical nerve head swelling (ONHS-RVO) based on the sites of venous occlusion.The percentages of POAG in different types of RVO were calculated.This study was approved by Ethic Committee of Peking University Third Hospital, and written informed consent was obtained from each patient before entering study cohort.
ResultsThree hundred and seventeen RVO patients finished screening of glaucoma, with the response rate 84.5%.The percentage of POAG is 8.2% in RVO patients, including 7.1% in the CRVO patients, 23.5% in HRVO patients and 6.2% in BRVO patients.The percentage of POAG was significantly higher in OC-RVO patients (27.9%) and NONHS-RVO patients (13.2%) than that in AV-RVO patients (4.7%) and ONHS-RVO patients (1.3%) (all at P<0.05).
ConclusionsThe overall percentage of POAG in RVO patients in China is 3-4 times higher than general population.Higher percentage of POAG is found in OC-RVO patients and NONHS-RVO patients, suggesting that pathogenesis of RVO is probably associated with the glaucomatous anatomic changes of optical nerve head.
Key words:
Glaucoma/statistics & numerical data; Retinal vein; Thrombosis/statistics & numerical data; Glaucoma, open angle; Retinal vein occlusion; Humans
Contributor Information
Ke Xu
Peking University Third Hospital, Peking University Eye Center, Beijing 100191, China
Lingling Wu
Zhizhong Ma
Yuling Liu
Fang Qian
