Although there are numerous case resource, there still exist a relatively long distance in clinical research in China in comparison with developing countries because of inadequate recognition and funding, which has greatly affected the development of standardization of clinical medical in China for the past few decades.With the deepening of recognition and increasing of special support to clinical medical research in China, the development based on clinic research will face new opportunities.As a result, it is necessary for ophthalmologists to explore clinical issues, leverage from the mega trend of clinical research and deliver high-quality results.To achieve this goal, ophthalmologists will have to constantly update their knowledge base, standardize clinical practice and improve diagnosis methods.So far, challenges persist in clinical research in ophthalmology as follows: It is difficult to get funding for clinical research project; It is difficult to get ethnics approval for clinical research project; The research design for forward-looking projects is yet to be standardized; Cross-disciplinary collaboration needs to be enhanced.This review was expected to inspire more attention from clinical research specialists and consequently more high-quality clinical studies.

Ophthalmology; Clinical research; Ethic principle; Multicenter randomized controlled clinical trials; Clinical trail registration; Prospective study