Internal limiting membrane (ILM) peeling technique has been widely used in the treatment of a variety of vitreoretinal diseases for the advantage of releasing vitreomacular traction.However, this routine approach was less effective in refractory macular disorders.Meanwhile, the technique and the use of stains could lead to structural and functional changes of macular.Therefore, to better preserve macular structure, modified ILM peeling techniques including inverted ILM flap technique, autologous transplantation of ILM technique and the foveola nonpeeling ILM technique emerged.Recent researches had demonstrated favorable structural and functional outcomes of these techniques on giant macular hole, refractory macular hole and high myopic macular hole.However, more long-term follow-up studies with larger samples are needed to confirm the current results.In this paper, we reviewed the progress of modified ILM peeling technique in vitreoretinal diseases.

Internal limiting membrane peeling; Inverted internal limiting membrane flap; Autologous transplantation of the internal limiting membrane; Foveolar nonpeeling internal limiting membrane