Clinical Sciences
The measurement of macular intraretinal layer volume and its influence factors in normal subjects
Jianxiang Ruan, Lixia Feng, Ling Chen
Published 2017-11-10
Cite as Chin J Exp Ophthalmol, 2017, 35(11): 1025-1029. DOI: 10.3760/cma.j.issn.2095-0160.2017.11.014
Abstract
BackgroundThe histopathological and functional changes are affected by age, gender and axial length (AL). However, whether these factors affect the volume and thickness of various layers of retina is not elucidated.Understanding macular intraretinal layer volume changes and influence factors can offer useful information for relevant clinical study.
ObjectiveThis study was to measure the influence of age, gender and AL on the volume of individual retinal layers at macula zone with optical coherence tomography (OCT) in normal population.
MethodsA cross-sectional study was carried out under the approval of Ethic Committee of Tongling People's Hospital.One hundred and thirty-four eyes of 92 healthy individuals who received physical examinations and ocular examinations by slit lamp microscope, 90 D pre-set lens, RM-8000A computer automatic optometry and non-contact tomometer were recruited from April to July 2016.The individuals were grouped based on gender or ages (7-14 years group, 15-49 years group, 50-80 years group). The retinal thickness and volume of different layers within 6 mm circle area around fovea were measured by Spectral-OCT with Posterior Pole mode and processed by the layered software.AL was measured with ODM-2100 A/B ultrasonic apparatus.
ResultsThe volume values of whole retinal thickness (WRL), retinal nerve fiber layer (RNFL), inner nuclear layer (INL) and outer plexiform layer (OPL) in males were (8.80±0.38), (0.92±0.09), (1.03±0.07) and (0.79±0.07)mm3, which were significantly increased in comparison with (8.66±0.34), (0.88±0.07), (1.00±0.07) and (0.77±0.06)mm3 in females (P=0.025, 0.027, 0.012, 0.030). The WRL, GCL and IPL volume values were largest in the 15-49 years group and least in the 7-14 years group, and the volume values of RNFL, outer nuclear layer (ONL), retinal pigment epithelium (RPE) and photoreceptors (PC) were significantly lower in the 7-14 years group and 50-80 years group than those in the 15-49 years group (all at P<0.01). The AL was negatively correlated with WRL, GCL and IPL volumes (r=-0.226, -0.385, -0.373, all at P<0.01).
ConclusionsThe retinal volume value at macular area is larger in men than that in women.The retinal volume area shows firstly increased and then decreased during aging.The AL shows a negative correlation with the macular volume.
Key words:
Tomography, optical coherence; Retina; Biometry; Influence factors; Human
Contributor Information
Jianxiang Ruan
Department of Ophthalmology, Affiliated First Hospital of Anhui Medical University, Hefei 230022, China
Lixia Feng
Department of Ophthalmology, Affiliated First Hospital of Anhui Medical University, Hefei 230022, China
Ling Chen
Department of Ophthalmology, Tongling People's Hospital, Tongling 244000, China
