Diabetic macular edema (DME) is a common reason for vision decrease.The concept of DME treatment regime has been changed to increase the vision-sight of patients since the onset of new treatment.Recent DME guidelines introduced the latest researches of DME, which raised new clinical suggestion and clinical pathway based on evidence-based medicine.Anti-vascular endothelial growth factor (VEGF) treatment is the first-line therapy for all types of DME, laser photocoagulation and intravitreal steroid injection are often the supplementary treatment except for some special cases in which they can be the substitution for anti-VEGF treatment.The regime for DME treatment now is combination.To understand and follow the guidelines can help us instruct and standardize our management on DME.

Diabetic macular edema/treatment; Anti-vascular endothelial growth factor; Laser photocoagulation; Intravitreal steroid injection