External ocular malignant tumors include tumors of eyelid, conjunctiva, lacrimal gland, orbital bone and other ocular malignant tumors.They are highly malignant, difficult to treat, prone to local invasion and distant metastasis, and seriously affect the appearance and function of patients, threatening visual acuity and life.The clinical manifestations of external ocular malignant tumors are diverse and the treatment is extremely complicated.Traditional surgical resection often requires extended resection or even orbital enucleation.The postoperative ocular structural defects are serious, and plastic and reconstructive surgery is extremely difficult.There is still a high recurrence rate after combined radiotherapy or chemotherapy postoperatively, and the risk of local invasion or distant metastasis is still unavoidable, the prognosis is poor.Vascular endothelial growth factor(VEGF) plays an important role in the occurrence, development, metastasis and other biological behaviors of malignant tumors by regulating the proliferation, differentiation, migration and other related mechanisms of malignant tumor cells.Anti-VEGF therapy has become a hot topic in the field of tumor treatment.Some progress has been made in the basic research and clinical application of external ocular malignant tumors.This article will review this issue.