Basic Science Researches
Impact of acute renal artery stenosis on tissue elasticity of the kidney: an animal study
Na Li, Xiaona Liu, Haining Zheng, Yixiao Han, Qinggui Ye, Tao Shen, Chaoyang Wen
Published 2017-03-01
Cite as Chin J Med Ultrasound(Electronic Edition), 2017, 14(3): 232-235. DOI: 10.3877/cma.j.issn.1672-6448.2017.03.013
Abstract
ObjectiveTo study the changes of Young′s modulus value of the renal cortex, vertebral body and sinus when there was a different degree of acute renal artery stenosis.
Methods10 Japanese white rabbits were used for this study. The left renal artery was dissected. An ultrasound probe was placed on the left kidney, Young′s modulus of the renal cortex, vertebral body and sinus were recorded using shear wave ultrasound elastic imaging technique during three stages: when the renal artery was intact (0% stenosis), tied with a suture (> 50% stenosis), and ligated (100% stenosis). Renal tissue elasticity with different degrees of renal artery stenosis were compared. Pathological study was carried out in the kidneys, each with either 0%, >50% or 100% renal artery stenosis.
ResultsThe mean values of Young′s modulus from the renal cortex, vertebral body and sinus with different degrees of renal artery stenosis were as follows: 0% stenosis, (16.31±1.70) kPa, (13.38±1.63) kPa, and (12.75±2.26) kPa; >50% stenosis, (14.16±2.34) kPa, (11.49±2.70) kPa, and (10.72±2.56) kPa; 100% stenosis, (11.35±1.48) kPa, (8.39±1.29) kPa, and (7.08±1.52) kPa. The mean value of Young′s modulus from the renal cortex was significantly higher than those from the renal vertebral body and sinus (P<0.05). The mean values of Young′s modulus from different parts of the kidney decreased progressively with an increase in renal artery stenosis (P<0.05). The pathological study demonstrated that with the increase in the severity of renal artery stenosis, glomerular volume, renal interstitial capillary diameter and red blood cells decreased. When renal artery stenosis reached 100%, there was patch degeneration and inflammatory cell infiltration within the renal interstitium, and mild degeneration of tubular epithelial cells with obscure cell borders.
ConclusionsThe value of Young′s modulus from the renal cortex was higher than those from the renal pyramid and sinus in rabbits. The values of Young′s modulus from the renal cortex, pyramid and sinus decreased with an increase in the severity of renal artery stenosis, which suggest that, in the study of the elasticity of the kidney, the renal artery blood flow dynamic state can obviously affect the value of the elasticity of the kidney.
Key words:
Renal artery obstruction; Elasticity imaging techniques; Rabbits
Contributor Information
Na Li
Department of Ultrasound, Chinese People′s Liberation Army General Hospital, Beijing 100853, China
Department of Auxiliary Diagnosis, the 463rd Hospital of Shenyang Military Region, Shenyang, Liaoning 110042, China
Xiaona Liu
Department of Ultrasound, Chinese People′s Liberation Army General Hospital, Beijing 100853, China
Department of Ultrasound, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, China
Haining Zheng
Department of Ultrasound, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China
Yixiao Han
Department of Ultrasound, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China
Qinggui Ye
Department of Ultrasound, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China
Tao Shen
Department of Auxiliary Diagnosis, the 463rd Hospital of Shenyang Military Region, Shenyang, Liaoning 110042, China
Chaoyang Wen
Department of Ultrasound, Chinese People′s Liberation Army General Hospital, Beijing 100853, China
Department of Ultrasound, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China
