Tuberculousis wound is an infections disease, which continues to be a clinical problem for its large number of patients and easy recurrence. At present, the pathogenesis of tuberculousis wounds is unclear. In order to understand its pathogenesis and effectiveness of treatment, it is necessary to reproduce an appropriate animal model. But so far, there is still no perfect animal model to mimic human tuberculosis. Since different animals have different sensitivity to mycobacterium tuberculosis, and their respective performance are different after infection, different animal models of tuberculousis wound have their own advantages and disadvantages. Guinea pigs and New Zealand rabbits are widely used in pathologic studies. Zebrafish are new animal models of tuberculosis wound, which are mainly used in the studies of molecular biology. Nonhuman primates are the best animal model to mimic human tuberculosis with irreplaceable advantages in many aspects. Although the granulomatous structure of mice model is not typical, the mice are the best choice for immunological studies. This review summarizes the characteristics of several animal models of tuberculosis wound.

Tuberculosis; Models, animal; Wounds