Organ Donation
Advancing extracorporeal organ perfusion technology and improving the utilization and quality of donor organs
Li Jianhui, Qiao Yinbiao, Jia Junjun, Jiang Wenshi, Xie Haiyang, Zhou Lin, Zheng Shusen
Published 2020-04-25
Cite as Chin J Transplant (Electronic Edition), 2020, 14(2): 83-86. DOI: 10.3877/cma.j.issn.1674-3903.2020.02.005
Abstract
Organ transplantation is the only effective treatment for end-stage diseases, and the scarcity of donor organ seriously hinders the development of organ transplantation. Increasing the utilization rate of marginal organs can partially alleviate the shortage of organs. With the continuous development of organ preservation technology, machine perfusion has gradually become an crucial research direction to improve the quality of donor organs. Machine perfusion is expected to be superior organ preservation technology than static cold storage and improves preservation environment and quality assessment system of the isolated donor organ, repairs marginal donor organs and improves organ utilization. We review the research progress of machine perfusion technology and the future development, through the fusion of medicine and engineering, the development of machine perfusion technology will improve the quality and utilization rate of donor organs.
Key words:
Organ donation; Ischemia reperfusion injury; Static cold storage; Machine perfusion; Marginal donor
Contributor Information
Li Jianhui
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Qiao Yinbiao
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Jia Junjun
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Jiang Wenshi
International Registry on Organ Donation and Transplantation, Shenzhen 518054, China
Xie Haiyang
Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Zhou Lin
Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Zheng Shusen
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
