Original Article
Efficiency of Oral N-acetylcyeteine for Chronic Pneumonia
huaping Huang, feng Liu, mingjing Chen, Jie Wang, meihua Liu, Jialiang Chen, xi Li
Published 2017-06-20
Cite as Chin J Lung Dis(Electronic Edition), 2017, 10(3): 267-270. DOI: 10.3877/cma.j.issn.1674-6902.2017.03.005
Abstract
ObjectiveTo investigate the clinical effect of N-acetylcyeteine in patients with chronic pneumonia, and explore a new approach of treatment to chronic pneumonia.
MethodsA total of 54 patients with chronic pneumonia were recruited into this study from the First Affiliated Hospital of Hainan Medical University between January 2012 and December 2015, and randomly divided into the following four groups: group A(n=11) received N-acetylcyeteine 0.6 g a day, group B(n=13) received N-acetylcyeteine 1.2 g a day, group C(n=15) received N-acetylcyeteine 1.8 g a day and group D(n=15) received without medication(control group). The patients were monitored monthly for 24 weeks. A complete blood count, blood chemistries, SpO2 and chest CT were recorded before and after therapy. In addition, chest CT was performed at week 4 and week 12.
ResultsIn comparation with the contrast group or group A, group B or group C could effectively decrease CT scores in patients with chronic pneumonia (P<0.05). But there was no significant difference between group B and group C(P=0.42).
ConclusionOral N-acetylcysteine can be used in chronic pneumonia. Recommended dosage of N-acetylcysteine in patients with chronic pneumonia is 1.2 g or 1.8 g a day for 24 week.
Key words:
Chronic pneumonia; N-acetylcyeteine; Clinical efficiency; Clinical research
Contributor Information
huaping Huang
Department of Respiratory Disease, the First Affiliated Hospital of Hainan Medical University, Respiratory Disease Institute of Hainan Medical University, Haikou 570102, China
feng Liu
Department of Respiratory Disease, the First Affiliated Hospital of Hainan Medical University, Respiratory Disease Institute of Hainan Medical University, Haikou 570102, China
mingjing Chen
Department of Pathology, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, China
Jie Wang
Department of Respiratory Disease, the First Affiliated Hospital of Hainan Medical University, Respiratory Disease Institute of Hainan Medical University, Haikou 570102, China
meihua Liu
Department of Respiratory Disease, the First Affiliated Hospital of Hainan Medical University, Respiratory Disease Institute of Hainan Medical University, Haikou 570102, China
Jialiang Chen
Department of Respiratory Disease, the First Affiliated Hospital of Hainan Medical University, Respiratory Disease Institute of Hainan Medical University, Haikou 570102, China
xi Li
Department of Respiratory Disease, the First Affiliated Hospital of Hainan Medical University, Respiratory Disease Institute of Hainan Medical University, Haikou 570102, China
