Aconiti lateralis radix praeparata (Fuzi) prescriptions are widely used in all stages of chronic kidney disease, and have significant and stable effects in improving clinical symptoms, reducing glucocorticoid side effects, and protecting renal function. This paper began with the efficacy and common clinical adverse reactions of Fuzi, introduced the understanding of the toxicity of Fuzi by traditional Chinese medicine and modern pharmacology, and analyzed the influencing factors of the toxic and side effects, including processing method, dosage, decoction way, drug matching detail, TCM syndrome, habitus, etc. At the same time, it summarized the indications of Fuzi, the usage and dosage, criteria for evaluation of efficacy, and compatibility and decoction methods of Fuzi, etc, in order to regulate its clinical use.