Original Article
Long-term results of squamous cell esophageal cancer after surgical treatment in China, single center experience of Shanghai Chest Hospital
Zhigang Li, Xiaobin Zhang, Xufeng Guo, Yifeng Sun, Yu Yang, Bin Li, Haiyong Gu, Rong Hua, Teng Mao
Published 2018-05-28
Cite as Chin J Thorac Surg(Electronic Edition), 2018, 05(2): 69-74. DOI: 10.3877/cma.j.issn.2095-8773.2018.02.01
Abstract
ObjectiveTo analyze the long-term survival rates and influencing factors of surgical treatment of esophageal squamous cell carcinoma.
MethodsAll patients with esophageal squamous cell carcinoma who underwent surgical treatment at Shanghai Chest Hospital from 2012 to 2014 were reviewed. 864 patients undergoing transthoracic surgery were selected as the study subjects. Their general conditions, surgical approaches, postoperative complications, and long-term survival outcomes were analyzed.
ResultsOf all the patients, 84.7% were men, and 44.9% and 30.4% were cII and cIII patients, respectively. Neoadjuvant therapy was used in 8.3% of patients. The right thoracic approach was used in 88.7% of patients. The proportion of minimally invasive surgery was 23.6%. The overall complication rate was 41.8%, and the 90-day mortality rate was 3.1%. The recurrence rate was 38.1%. The 1-year, 3-year, and 5-year overall survival rates were 85.5%, 61.2%, and 49.3%, respectively. Minimally invasive surgery improved long-term survival (MIE vs OPEN 66.5% vs 44.0%, P<0.001). Adjuvant therapy was shown to improve overall survival in both lymph node positive and negative T3N0 patients (33.3% vs 31.5%, P=0.001; 66.0% vs 49.5%, P=0.004).
ConclusionsSurgical resection combined with postoperative adjuvant therapy can achieve satisfactory long-term survival of esophageal squamous cell carcinoma. The role of neoadjuvant therapy requires further study.
Key words:
Esophageal cancer; Squamous cell cancer; Esophagectomy; Minimally invasive surgery
Contributor Information
Zhigang Li
Department of Thoracic Surgery, Section of Esophageal Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China
Xiaobin Zhang
Xufeng Guo
Yifeng Sun
Yu Yang
Bin Li
Haiyong Gu
Rong Hua
Teng Mao