Osteoporosis
The relationship between Serum ferritin and Osteoporosis
Lu Jingjing, Li Xing, Lou Pingping, Zhang Jie, Liu Yan, Zhou Yaru.
Published 2020-04-05
Cite as Chin J Geriatr Orthop Rehabil(Electronic Edition), 2020, 06(2): 111-116. DOI: 10.3877/cma.j.issn.2096-0263.2020.02.009
Abstract
ObjectiveTo analyze the difference of serum ferritin among postmenopausal women and men older than 50 years with different bone mass, and to explore the correlation between serum ferritin level and bone mineral density (BMD).
MethodsPostmenopausal women (n=131) and men (n=65) older than 50 years who received DEXA from September 2018 to February 2019 were enrolled in this study. They were divided into normal (46 cases), osteopenia (68 cases) and osteoporosis (82 cases) groups. Clinical data and biochemical parameters were collected. The level of serum ferritin was detected, and its correlation with BMDwas also determined.
Results1.Compared with normal and osteopenia group, serum ferritin level was significantly increased in osteoporosis group [174.25 (160.85, 210.42) ng/ml vs. 99.50 (91.55, 128.51) ng/ml and 103.36 (93.26, 113.46) ng/ml, χ 2=100.573, P<0.05]. 2. The level of serum ferritin was negatively correlated with BMD in hip and lumbar spine (hipr=-0.487, P<0.05; lumbar vertebraer=-0.531, P<0.05). 3. Multivariate binary logistic regression analysis showed that body weight was the protective factor for osteoporosis (r=0.049, P<0.05), and serum ferritin was the risk factor for osteoporosis (r=-0.018, P<0.05).
ConclusionSerum ferritin plays an important role in the prevalence of osteoporosis, which may be a risk factor for osteoporosis.
Key words:
Bone density; Osteoporosis; Iron overload; Serum ferritin
Contributor Information
Lu Jingjing
Departmen tof Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
Li Xing
Departmen tof Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
Lou Pingping
Departmen tof Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
Zhang Jie
Departmen tof Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
Liu Yan
Departmen tof Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
Zhou Yaru.
Departmen tof Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China