To explore the clinical characteristics of the neurological damage caused by the a buse of laughing gas(nitrous oxide).

The clinical characteristics and outcome of the nervous system lesions of a patient abusing laughing gas were retrospectively anaylzed.

The pathological changes of the nervous system caused by the nitrous oxide were easily missed in the clinic,with the most young people.The laughing gas poisoning resulted in clinical manifestations of nervous system lesions (the spinal cord damage of subacute combined degeneration,in order to exercise axon damage to give priority to the length of the dependence of peripheral neuropathy,and ataxia,and so on),and there was vitamin B12 level drop,high homocysteine levels.Magnetic resonance (MRI) showed the irregular white mass demyelination of the cervical spinal cord and the posterior cord of the thoracic spinal cord,and the T2 WI of the spinal cord showed the "V" signal of the neck or thoracic pulp.The main manifestation of the electrogram was the peripheral neuropathy,which was mainly caused by the injury of the motor axon.

Patients with subacute or chronic onset of youth,performance and change,peripheral nerve damage,and so on,need to ask for details of any contact laughing gas.The blood vitamin B12,homocysteine levels,cervical spinal magnetic resonance and EMG were used to make clear diagnosis,probably ruled out laughing gas poisoning.

Laughing gas; Abuse; The nervous system; Damage