Osteoporotic fracture is a common bone disease among elderly and middle-aged people. It is also a severe stage of osteoporosis which has the characteristics of high morbidity, disability, fatality, and medical costs, posing a heavy burden on patients, their families, and society. A standardized diagnosis and treatment of osteoporotic fractures are of great importance to clinical work and the Healthy China strategy. The Chinese Orthopaedic Association has developed the guidelines for the diagnosis and treatment of osteoporotic fractures (2022 edition), which are updated from the 2017 edition. The main updated content includes the definition, epidemiology, and treatment strategies of osteoporotic fractures, as well as anti-osteoporosis drugs and their effects on fracture healing, prevention of refractures, and perioperative management. With the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) grading system and Reporting Items for Practice Guidelines in Healthcare (RIGHT), 21 clinical issues and corresponding evidence-based medical recommendations are finally formed, aiming to improve both the scientific and pioneering nature of the diagnosis and the treatment of osteoporotic fractures, and finally put the quality of medical services that "oriented to people's life and health" to a higher level.