Objective To evaluate the efficacy and safety of Aescuven forte on treating elderly patients with scrotal edema. Methods Eighty-two patients with scrotal edema were randomly divided into control group and treatment group（41cases for each group）. Patients in the control group received physical therapy as well as oral Furosemide tablets for 20 mg and 2 times/ d,while in treatment group were given 450 mg oral Aescuven forte （2 times/ d）,and 300 mg Aescuven forte at 10 d besides the treatment as the control group. The total treatment period was 20 days. The information of scrotal volume,score of discomfort or pain,scrotal ulcer healing time were collected. Results After 20 d treatment,the scrotal diameter in treatment group was（7. 81 ± 0. 64）cm,shorter than that before treatment（13. 30 ± 0. 73）cm,and the difference was statistically significant（ t = 2. 201,P〈 0. 05）. Scrotal diameter of the control group before and after treatment were（13. 25 ± 0. 71）,（10. 71 ± 0. 65） cm,and there were statistically significant differences（ t = 2. 369,P 〈 0. 05）. After treatment,the decreases degree of scrotal diameter in the treatment group was higher than control group（ t = 2. 304,P 〈0. 05）. After treatment,scrotal ulcer healing rate,healing time in treatment groups were 100%（11 / 11）and（14. 1 ± 1. 8）d, and 70%（7 / 10）and（17. 1 ± 1. 9）d in control group,and there were significant difference（ χ^2 = 4. 880,P= 0. 030;t = 2. 713,P = 0. 016）. There was no significant difference in terms of the clinical symptom score between two group before treatment（ P 〉0. 05）. After treatment,the level of pain and discomfort,voiding symptoms,life quality score were（7. 35 ± 3. 08）,（3. 43 ± 1. 91）,（5. 89 ± 2. 11）,lower than those in the control group（（8. 47 ± 3. 07）,（4. 52 ± 2. 19）,（6. 96 ± 2. 13））,and the differences were statistically significant （t = 2. 260,2. 382,2. 319,P 〈0. 05）. The total effective rate of treatment group was 87. 8%（36 / 41）,higher than that in control group（65. 8%（27 / 41））,and there was significant difference（χ^2 = 4. 580,P〈 0. 01）. In the periods of treatment,no adverse reaction between two groups was occurred. Conclusion The use of Aescuven forte combine with diuretic has a synergistic effect and significantly improve the clinical symptoms of elderly patients with scrotal edema in terms of eliminating edema,promoting healing,relieving scrotal ulcer wound pain, improving voiding symptoms and the quality of life. And there is no side effect.