Gluconeogenesis is a process that translates lactate,glycerin and glycogenic amino acid into glucose or glycogen.It is a major source of endogenous glucose production and of importance on the whole body glucose homeostasis.More and more studies confirm that intestine can utilize glutamine and glyc-erin to synthetize glucose in fasting,lacking of hepatic glycogen and diabetic status.Distincting from hepatic gluconeogenesis,intestinal glucose not only contributes to the glucose homeostasis,but also reduces food-in-take and improves insulin sensitivity.Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass,which might have beneficial consequences on obesity and type 2 diabetes.