Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes mellitus and is the leading cause of end-stage renal disease (ESRD). Lysophosphatidic acid/lysophosphatidic acid receptor 1 (LPA/LPA₁) signaling pathway mediates a series of pathological processes by triggering downstream signaling cascade and is an important regulatory pathway for many diseases. In terms of DKD, LPA/LPA₁ signaling pathway may play a role in mesangial cell proliferation, fibrosis, podocyte injury, inflammation and oxidative stress to promote the progression of DKD. However, there are limited reports on the specific molecular mechanism of this pathway in the pathogenesis of DKD. In-depth study of the role of LPA/LPA₁ signaling pathway is of great significance for the diagnosis and treatment of DKD.

Lysophosphatidic acid; Signaling pathway; Diabetic kidney disease