Diabetes is the common chronic disease in China. Exercise therapy is the main way of life intervention in diabetes, and throughout the entire treatment.Exercise can reduce the incidence of diabetes and the risk of death.However, diabetes itself can also decrease cardiorespiratory endurance and damage vascular endothelium and mitochondrial function, etc, which can decline exercise capacity. Exercise can trigger a series of intricate molecular pathways to improve insulin resistance and control blood glucose, which is independent of the insulin pathway. But whether exercise can repair the damage caused by diabetes and the molecular mechanism of interaction between the two is not fully clear. Clarifying the effect and mechanisms of diabetes on exercise capacity could provide a basis for better exercise therapy and lay the foundation for exploring various motor mimics and finding new drug targets.