Due to the complexity of the pathogenesis and the diversity of the affected organs, most of traditional animal models only possess some parts of metabolic phenotypes of diabetes. Considering the lack of uniform inducing protocol and modeling standards, there are shortcomings in the induction and phenotype among traditional models of diabetes and diabetic complications. Application of gene editing and genetic breeding to generate the models of diabetes and diabetic complications conquer some of the shortcomings mentioned above, which contains considerable application value. Therefore, it is crucial to choose appropriate animal models to ensure the reliability of research data and the conclusion. Furthermore, it may be helpful for understanding the pathogenesis of diabetes and contributing to the development of anti-diabetic drugs.