Original Article
Dihydromyricin ameliorates non-alcoholic fatty liver disease by inhibiting lipid synthesis
Leng Qingyang, Li Chang, Zhou Jianhua, Liu Lu, Li Na, Gong Sa, Zhang Hao, Li Xiaohua
Published 2020-11-20
Cite as Int J Endocrinol Metab, 2020, 40(6): 376-381,F3. DOI: 10.3760/cma.j.cn121383-20200205-02004
Abstract
ObjectiveTo explore the effect of dihydromyricin on the improvement of non-alcoholic fatty liver disease and its potential mechanism.
MethodsThe mice of non-alcoholic fatty liver disease model induced by high fat diet were randomly divided into two groups using a random number table, one group was given dihydromyricin (100 mg·kg-1·d-1) by gavage, and the other group was given the corresponding volume of normal saline. During this period, body weight and food intake were measured weekly. After treatment for 4 weeks, the glucose tolerance, insulin release and insulin tolerance tests were measured. The lipid accumulation in the liver was detected and the level of serum lipid, the expression of lipid metabolism-related genes and liver functions were analyzed.
ResultsAfter treatment with dihydromyricin, the mice had significantly lower body weight, better metabolic profiles and liver function. In addition, the mice treated by dihydromyricin had less steatosis and triglyceride content in liver(t=2.161-7.315, all P<0.05). The mRNA and protein expression levels of sterol regulatory element binding protein 1c (SREBP-1c,t=3.2, P<0.05) and fatty acid synthase (FASN,t=7.116, P<0.01) were significantly down-regulated.
ConclusionDihydromyricin can inhibit the de novo synthesis of liver lipids by reducing the expression of SREBP-1c/FASN and ameliorate non-alcoholic fatty liver disease.
Key words:
Dihydromyricin; Non-alcoholic fatty liver disease; Lipid synthesis; Sterol regulatory-element binding proteins 1c; Fatty acid synthase
Contributor Information
Leng Qingyang
Department of Endocrinology, The Seventh People′s Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Li Chang
Department of Endocrinology, The Seventh People′s Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Zhou Jianhua
Department of Endocrinology, The Seventh People′s Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Liu Lu
Department of Endocrinology, The Seventh People′s Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Li Na
Department of Endocrinology, The Seventh People′s Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Gong Sa
Department of Endocrinology, The Seventh People′s Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Zhang Hao
Department of Endocrinology, The Seventh People′s Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Li Xiaohua
Department of Endocrinology, The Seventh People′s Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
