Review Article
Hyperuricemia and adverse pregnancy outcomes
Niu Ziru, Lu Qiang
Published 2022-03-20
Cite as Int J Endocrinol Metab, 2022, 42(2): 142-145. DOI: 10.3760/cma.j.cn121383-20201114-11029
Abstract
Uric acid is a product of human metabolism. The rate of uric acid production and excretion in normal human body is basically constant. The change of uric acid level in vivo can reflect the situation of human metabolism, immunity and so on. Levels of some metabolites levels fluctuate in pregnant women, including elevated blood uric acid. Studies have found that pregnancy-induced hypertension, gestational diabetes and other complications related to the increase of serum uric acid levels. Moreover, the increase of serum uric acid level will affect the fetal and pregnant women′s postpartum physical condition to some extent, leading to premature delivery, macrosomia, congenital abnormalities and other adverse pregnancy outcomes. However, the pathophysiological mechanism of high uric acid affecting gestational diseases is not very clear.
Key words:
Hyperuricemia; Pregnancy complications; Pregnancy outcomes
Contributor Information
Niu Ziru
Department of Endocrinology and Metabolic Diseases, Hebei Medical University, Shijiazhuang 050000, China
Lu Qiang
Department of Endocrinology and Metabolic Diseases, Hebei Medical University, Shijiazhuang 050000, China
Department of Endocrinology, the First Hospital of Qinhuangdao, Qinhuangdao 066000, China