Advances in molecular genetics of maturity-onset diabetes of the young
Qin Xiaoyan, Shi Ping, Guan Qingbo, Zhao Jiajun, Xu Chao
Abstract
Maturity-onset diabetes of the young (MODY) is an autosomal dominant monogenic diabetes mellitus. At present, a total of 14 kinds of mutated genes have been found to be related to MODY, and these genes directly or indirectly play roles in insulin synthesis and release pathways, thereby affecting blood glucose homeostasis. Different hypoglycemic drugs can be selected according to the different action modes of insulin in the body caused by mutant genes. This enables precise treatment of this particular type of diabetes. This article summarizes the genetic research progress of 14 kinds of MODY, including the gene mutations of MODY and the clinical characteristics of the disease. In order to improve the accuracy of diagnosis and the quality of life of MODY patients; the treatment plan and future research hotspots are also suggested.
Key words:
Maturity-onset diabetes of the young; Gene mutation; Molecular genetic; Pancreatic β cells
Contributor Information
Qin Xiaoyan
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan 250021, China
Shi Ping
Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, China
Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan 250021, China
Guan Qingbo
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, China
Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan 250021, China
Zhao Jiajun
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, China
Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan 250021, China
Xu Chao
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, China
Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan 250021, China
