Original Article
Effect of 5∶2 fasting diet on body weight and glucose and lipid metabolism in patients with metabolic syndrome
Xiao Yanxin, Ma Zhaopeng, Wu Xiaodan, Wang Hongsu, Wang Jun
Published 2023-05-20
Cite as Int J Endocrinol Metab, 2023, 43(3): 242-246. DOI: 10.3760/cma.j.cn121383-20220223-02054
Abstract
ObjectiveTo observe the effect of 5∶2 intermittent fasting diet on body weight and metabolic profile in patients with metabolic syndrome.
MethodsA total of 56 obese patients with metabolic syndrome were divided into 5∶2 intermittent fasting treatment group(n=36) and general diet control treatment group (n=20). Patients in each group received 5∶2 intermittent fasting and general diet control for 16 weeks. Body shape indexes and metabolic profile were observed after treatment.
ResultsAfter 16 weeks of treatment, all body shape indexes such as body mass index, waist circumference, skeletal muscle content, body fat, body fat rate and visceral fat area in the 5∶2 intermittent fasting treatment group decreased significantly compared with those before treatment (P<0.05). The levels of metabolic profile including systolic blood pressure, diastolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, triglycerides, fasting blood glucose, 2 hour postprandial blood glucose, uric acid and HOMA-IR decreased significantly compared with those before treatment, and the level of high-density lipoprotein cholesterol increased significantly (P<0.05). Compared with general diet control group, body mass index, body fat, body fat rate and visceral fat area, systolic blood pressure, diastolic blood pressure, low density lipoprotein cholesterol, triglyceride, fasting blood glucose, 2 hour postprandial blood glucose and HOMA-IR level in the 5∶2 intermittent fasting treatment group were lower after 16 weeks of treatment (P<0.05). After 16 weeks of treatment, the proportion of obesity, dyslipidemia, hyperuricemia, abnormal glucose metabolism and nonalcoholic fatty liver disease in the 5∶2 intermittent fasting treatment group decreased compared with that before treatment (P<0.05).
Conclusions5∶2 intermittent fasting diet can reduce body weight and body fat ratio of patients with metabolic syndrome, improve the disorder of glucose and lipid metabolism and reduce insulin resistance, and is better than general diet control treatment.
Key words:
5∶2 intermittent fasting diet; Metabolic syndrome; Obesity
Contributor Information
Xiao Yanxin
Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding 071000, China
Ma Zhaopeng
Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding 071000, China
Wu Xiaodan
Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding 071000, China
Wang Hongsu
Department of Radiology, the 82nd Army Hospital of the PLA, Baoding 071000, China
Wang Jun
Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding 071000, China
