Inflammation is an important mechanism for the host to resist external infection and injury. Under normal conditions, adaptive inflammatory response not only is conducive to the repair of damaged cells and tissues, but plays an important role to promote the internal environment to restored homeostasis. However, when the immune function is damaged, the unresolved and uncontrolled inflammation will cause non-specific tissue damage, which is linked to a variety of inflammatory diseases. In the acute inflammation, resolvins, a group of endogenous small molecular lipid mediators which are biosynthesized by polyunsaturated fatty acids, possess anti-inflammatory and pro-resolving actions, which are benefit for the repair of damaged tissue. Therefore, it is helpful to deeply explore the mechanisms of resolvins in inflammation-resolution phases of acute lung injury (ALI) and sepsis, which are favor of understanding the complex processes and provide new treatment for the inflammatory diseases thereby reducing the mortality in the intensive care unit (ICU).

Resolvins; Inflammation; Acute lung injury; Sepsis