Clinical Research
Values of contrast-enhanced ultrasound and thyroglobulin measurement in fine-needle aspiration for detecting lateral cervical lymph node metastasis of papillary thyroid carcinoma
Liu Naxiang, Tang Lina, Shen Youhong, Wu Zhougui, Du Zhongshi, Wang Yaoqin, Huang Weiqin, Chen Yijie
Published 2020-12-25
Cite as Chin J Ultrasonogr, 2020, 29(12): 1060-1066. DOI: 10.3760/cma.j.cn131148-20200806-00637
Abstract
ObjectiveTo investigate the values of contrast-enhanced ultrasound (CEUS) and thyroglobulin measurement in fine-needle aspiration(FNA-Tg) in detecting papillary thyroid carcinoma(PTC) metastatic lateral cervical lymph nodes, and analyze the impacts of different factors on the sensitivities of CEUS and FNA-Tg.
MethodsOne hundred and twenty-two lymph nodes from 109 patients who underwent aspiration biopsy and cervical lymphadenectomy nodes were enrolled in Fujian Cancer Hospital from November 2018 to January 2020. CEUS and FNA-Tg results were acquired in all patients. The diagnostic values of CEUS, FNA-Tg and the combination of the two methods were compared in suspicious PTC metastatic lymph nodes. The impacts of lymph nodes size, lymph nodes cystic areas and hyper-echoic areas on the sensitivities of CEUS and FNA-Tg were analyzed.
ResultsAmong the 122 lymph nodes, 74 were metastasis lymph nodes and 48 were non-metastasis lymph nodes. There were significant differences between them in hyperechoic areas and marginal blood flow (P<0.05). There were significant differences in CEUS enhancement direction and uniformity (P<0.05). The diagnostic sensitivities of CEUS, FNA-Tg and the combination of the two methods were 86.5%, 94.6% and 100%, respectively, the specificities were 50%, 95.8% and 50%, respectively, the accuracies were 72.1%, 95.1% and 80.3%, respectively. The hyper-echoic areas of lymph nodes had effects on the sensitivity of CEUS(P<0.05), while they had no effect on the sensitivity of FNA-Tg(P=0.77). The size and cystic areas of lymph nodes had no effect on the sensitivity of CEUS and FNA-Tg(P=0.88, 0.95, 0.35, 0.89).
ConclusionsFNA-Tg has high specificity and accuracy in the diagnosis of metastatic lymph nodes in PTC. Combined with CEUS, the sensitivity is significantly improved, and FNA-Tg is not affected by the size of lymph nodes, cystic area and hyper-echoic areas. It is of great significance in the diagnosis of PTC metastatic lymph nodes.
Key words:
Ultrasonography; Lymph node metastasis; Contrast media; Papillary thyroid carcinoma; Thyroglobulin
Contributor Information
Liu Naxiang
Department of Ultrasound, Fujian Cancer Hospital, Affiliated Tumor Hospital of Fujian Medical University, Fuzhou 350014, China
Tang Lina
Department of Ultrasound, Fujian Cancer Hospital, Affiliated Tumor Hospital of Fujian Medical University, Fuzhou 350014, China
Shen Youhong
Department of Ultrasound, Fujian Cancer Hospital, Affiliated Tumor Hospital of Fujian Medical University, Fuzhou 350014, China
Wu Zhougui
Department of Ultrasound, Fujian Cancer Hospital, Affiliated Tumor Hospital of Fujian Medical University, Fuzhou 350014, China
Du Zhongshi
Department of Ultrasound, Fujian Cancer Hospital, Affiliated Tumor Hospital of Fujian Medical University, Fuzhou 350014, China
Wang Yaoqin
Department of Ultrasound, Fujian Cancer Hospital, Affiliated Tumor Hospital of Fujian Medical University, Fuzhou 350014, China
Huang Weiqin
Department of Ultrasound, Fujian Cancer Hospital, Affiliated Tumor Hospital of Fujian Medical University, Fuzhou 350014, China
Chen Yijie
Department of Ultrasound, Fujian Cancer Hospital, Affiliated Tumor Hospital of Fujian Medical University, Fuzhou 350014, China
