The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules.As a pattern-recognition receptor capable of binding a diverse range of ligands,it interacts with many signaling molecules,regulates their activation and interferes the process of diseases.As reported,RAGE expression is demonstrated to be abnormal in experimental models of pulmonary fibrosis.Through regulating the epithelial-mesenchymal trasnsformation,RAGE adjusts the deposition of extracellular matrix,in order to control the progress of lung fibrosis.Indeed,blockade of RAGE may have been implicated in the onset and development of idiopathic pulmonary fibrosis.Understanding the precise molecular interactions that RAGE regulates the onset and development of idiopathic pulmonary fibrosis will hopefully lead to the identification of novel therapeutic targets for idiopathic pulmonary fibrosis.