Research progress on mechanism of Pseudomonas aeruginosa efflux pumps and development of potential efflux inhibitors
Zhang Huiling, Xu Xiaoxiao, Sheng Anqun, Zhang Xueya, Zhang Yan, Shao Youyou, Li Changchong
Published 2014-01-20
Cite as Int J Respir, 2014,34(02): 107-110. DOI: 10.3760/cma.j.issn.1673-436x.2014.02.006
Abstract
Pseudomonas aeruginosa is a common clinical conditional pathogen.With the extensive and irrational use of antimcrobial agents,the resistance rate of Pseudomonas aeruginosa is increasing year by year.The active efflux pump system is the primary antimcrobial-resistance mechanism that exists in Pseudomonas aeruginosa.This paper aims to summarize the articles published recently,and reviews the structure,substrates,the inhibition mechanism,and classification of efflux pump inhibitors.
Key words:
Pseudomonas aeruginosa; Efflux pump system; Inhibitors of efflux pump
Contributor Information
Zhang Huiling
Department of Respiratory Medicine,the Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China
Xu Xiaoxiao
Department of Respiratory Medicine,the Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China
Sheng Anqun
Department of Respiratory Medicine,the Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China
Zhang Xueya
Department of Respiratory Medicine,the Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China
Zhang Yan
Department of Respiratory Medicine,the Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China
Shao Youyou
Department of Respiratory Medicine,the Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China
Li Changchong
Department of Respiratory Medicine,the Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China
